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Objectives: To conduct a systematic review and meta-analysis regarding the efficacy and safety of inhaled corticosteroids for COPD exacerbations(including COPD, bronchiolitis and lung transplant). Search strategy: MEDLINE, EMBASE, CINAHL, Cochrane Library, PEDro, ScienceDirect Seeking: any journal or author Summary of results: Among published peer-reviewed studies, inhaled immunosuppressive agents were associated with less severe episodes, fewer patients taking anti-inflammatory drugs and with less pulmonary complications. In a separate meta-analysis there was evidence that inhaled agents have a lower risk of respiratory complications. The number needed to treat for treatment-related toxicity was reduced for inhaled corticosteroids. Authors' conclusions: In the absence of evidence of an association between short-term inhaled corticosteroids and adverse events, inhalation therapy for chronic COPD exacerbations may benefit patients in the long term. The evidence on the efficacy and safety of inhaled immunosuppressive agents in obstructive pulmonary disease and in COPD exacerbations was inconclusive and needs future studies. Similar articles: